Cinnamic acids and derivatives
Medchemexpress LLC Z-Entacapone | 145195-63-7 | 305.29 | 25 MG
(Z)-Entacapone is a metabolite of the catechol-O-methyltransferase (COMT) inhibitor Entacapone. It is also a potential impurity found in commercial preparations of Entacapone and a degradant of Entacapone formed by UV light exposure.
- Metabolite of the catechol-O-methyltransferase (COMT) inhibitor Entacapone
- Potential impurity in commercial Entacapone preparations
- Degradant of Entacapone formed by UV light exposure
- Molecular formula: C14H15N3O5
- SMILES: O=C(N(CC)CC)/C(C#N)=C\C1=CC([N+]([O-])=O)=C(O)C(O)=C1
- Targets COMT
- Involves metabolic enzyme/protease and neuronal signaling pathways
Apexbio Technology LLC Entacapone 130929-57-6 10mg
Entacapone (CAS 130929-57-6) is a selective second-generation inhibitor of catechol-O-methyltransferase (COMT) It demonstrates potent inhibition of total COMT in mouse liver with reported IC50 and Ki values of 20 1 nM and 10 7 nM respectively In rat models IC50 values for soluble COMT and membrane-bound COMT are 14 3 nM and 73 3 nM Entacapone is primarily utilized in research as an adjunct to levodopa and dopa decarboxylase inhibitor regimens in Parkinson s disease studies given its ability to suppress the formation of 3-O-methyldopa thereby enhancing levodopa bioavailability and prolonging its pharmacological effect
Sigma Aldrich Fine Chemicals Biosciences Curcumin from Curcuma long50G
Curcumin from Curcuma long50G
Cayman Chemical Curcumin, Purity: ≥90%, CAS: 458-37-7, 100 g
A yellow pigment with diverse biological activities; inhibits NO production (IC50 = 6 μM) and reduces iNOS activity in LPS-stimulated RAW 264.7 cells; inhibits release of histamine and the inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-8 from HMC-1 mast cells; decreases serum levels of histamine and TNF-α, inhibits histopathological changes of nasal mucosa, and decreases the number of sneezes and nasal rubbing in a mouse model of ovalbumin-induced rhinitis; prevents ovalbumin-induced accumulation of 3-NT in mouse heart; reduces TPA-induced tumor formation in mouse skin (1-10 μmol); reduces the number of tongue neoplasms and preneoplastic lesions induced by 4-NQO in rats
Medchemexpress LLC Tyrphostin AG1433 | 168835-90-3 | 99.1% | 1 ML
Tyrphostin AG1433 is a small-molecule tyrosine kinase inhibitor selective for PDGFRβ, supplied as a 10 mM solution in DMSO (1 mL) for research use. The compound has molecular formula C16H14N2O2 and molecular weight 266.29 g·mol⁻¹.
- Supplied as a 10 mM solution in DMSO, 1 mL.
- High purity (≈99.1%) suitable for biological research.
- Molecular formula C16H14N2O2; molecular weight 266.29 g·mol⁻¹.
- Also available as solid in multiple milligram quantities for custom preparations.
- For research use only; not for human or veterinary applications.
Apexbio Technology LLC Tyrphostin A1 2826-26-8 50mg
Tyrphostin A1 (CAS 2826-26-8) is a small molecule inhibitor targeting tyrosine kinase activity specifically involved in disrupting intracellular signaling pathways in immune cells It has been shown to interfere with CD40 ligand-induced signaling resulting in suppressed interleukin-12 (IL-12) secretion by macrophages and reduced differentiation of antigen-induced T helper 1 (Th1) cells Tyrphostin A1 is widely utilized in studies investigating cell-to-cell signaling immune response modulation and the mechanisms underlying inflammatory processes particularly in the context of autoimmune disease models
Selleck Chemical LLC Curcumin S1848-1g
Curcumin (Diferuloylmethane Natural Yellow 3 Turmeric yellow) is the principal curcuminoid of the popular Indian spice turmeric which is a member of the ginger family (Zingiberaceae) It is an inhibitor of p300 histone acetylatransferase IC50 25 M and Histone deacetylase (HDAC) activates Nrf2 pathway and supresses the activation of NF- B Curcumin induces mitophagy autophagy apoptosis and cell cycle arrest with antitumor activity Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death Curcumin exhibits anti-infective properties against various human pathogens like the influenza virus hepatitis C virus HIV and so on
![Medchemexpress LLC 2-[(3,4-dihydroxy-5-nitrophenyl)methylidene]propanedinitrile | 116313-73-6 | 98.7% | 231.16 g/mol | C10H5N3O4 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000247989.png-250.jpg)
Medchemexpress LLC 2-[(3,4-dihydroxy-5-nitrophenyl)methylidene]propanedinitrile | 116313-73-6 | 98.7% | 231.16 g/mol | C10H5N3O4 | 25 MG
Tyrphostin AG 1288 is a small-molecule tyrosine kinase inhibitor used in biochemical and cellular research to probe tyrosine kinase-dependent signaling pathways, ICAM1 expression, and TNFα-mediated cytotoxicity. It is supplied as a high-purity research reagent intended for in vitro assays.
- High purity suitable for analytical and cell-based assays.
- Useful for investigating tyrosine kinase signaling pathways.
- Inhibits ICAM1 expression and TNFα-mediated cytotoxicity in vitro.
- Supplied as a stable, solid reagent for easy handling and storage.
- Batch-tested with a certificate of analysis for lot verification.
- Compatible with common solvents for assay formulation.
Medchemexpress LLC Curcumin | 458-37-7 | 98.6% | 10 MM * 1 ML
Curcumin | 458-37-7 | 98.6% | 10 MM * 1 ML
Chem-Impex International, Inc. trans-4-Bromocinnamic acid | MFCD00004394 | 25G
trans-4-Bromocinnamic acid, MFCD00004394, 25G
Medchemexpress LLC Ethyl α-D-galactoside | 15486-24-5 | ≥97.0% | 208.21 g/mol | C8H16O6 | 10 MG
Eleutheroside C (Ethyl α-D-galactoside) is a naturally occurring glycoside isolated from the bulbs of Polianthes tuberosa and supplied for laboratory research use. The compound is provided in milligram-scale quantities and is characterized by a reported molecular weight of 208.21 g/mol, CAS 15486-24-5, and a stated purity of ≥97%.
- Intended for research use only, not for human or veterinary use.
- High stated purity for analytical and biochemical applications.
- Supplied in milligram-scale quantities for small-scale experiments.
- Characterized by published molecular weight and CAS registry number for traceability.
Medchemexpress LLC 2-Hydroxycinnamic acid | 614-60-8 | MFCD00004379 | 98.71% | 164.16 | 100 MG
2-Hydroxycinnamic acid (Standard) serves as the analytical standard for 2-Hydroxycinnamic acid, intended for research and analytical applications. It is a phenolic acid possessing antimicrobial and antioxidant properties. This analytical standard grade compound is commonly employed in qualitative, quantitative, and methodological research experiments, including HPLC, GC, and MS.
- Demonstrates antimicrobial activity against *Staphylococcus aureus* without susceptibility to drug resistance.
- Exhibits inhibitory effects on HIV/SARS-CoV S pseudovirus infection, with an IC50 of 0.3 mM.
- Possesses neuroprotective activity.
- Possesses antitumor activity.